Voltammetric study and surface pressure isotherms describing Flunitrazepam incorporation into a distearoylphosphatidic acid film adsorbed at the air/water and water/1,2-dichloroethane interfaces

COLQUI QUIROGA MONICA; LORENA M.A. MONZON; LIDIA M. YUDI

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2011 vol. 56 p. 7022 - 7022

he effect of Flunitrazepam (FNTZ) on molecular packing of distearoylphosphatidic acid (DSPA) adsorbed at the air / water and the water / 1, 2 – dichloroethane interfaces was investigated using cyclic voltammetry (CV) and surface pressure – molecular area isotherm. FNTZ incorporation into the DSPA monolayer changes the state of the film. The results indicate that a structuring effect dependent on the pH and the cation present in the base aqueous electrolyte takes place, which leads to a decrease in the permeability of the film.