Quantitative determination of erythromycin and its hydrolysis products by cyclic voltammetry at the interface between water and 1,2-dichloroethane

L.M. YUDI; A.M. BARUZZI; V.M. SOLÍS

ELSEVIER SCIENCE SA

Lugar: Amsterdam; Año: 1993 vol. 360 p. 211 - 211

n electrochemical method for quantifying erythromycin (Er) salts and their hydrolysis products is described. Cyclic voltammetry at the water/1,2-dichloroethane interface in a four-electrode system was used. A linear relationship between Ip and the erythromycin concentration was obtained up to the solubility limit of the antibiotic. The various hydrolysis products which can be obtained in acid or basic solutions were characterized by their respective transfer potentials. Similar hydrolysis products were observed for aged solutions of Er lactobionate.