Extracellular lipase of Candida albicans mediate cell injury and steatosis in vitro

PARAJE MG; CORREA SG; RENNA MS; THEUMER M; SOTOMAYOR CE

NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS

Año: 2008 vol. 54 p. 647 - 647

p class="MsoNormal" style="MARGIN: 0pt; TEXT-INDENT: 14.2pt; LINE-HEIGHT: 150%; TEXT-ALIGN: justify; tab-stops: 285.75pt">Virulence depends on opposing reactions between  host and pathogen and is intrinsically linked to the host immune-status. Virulence factors rely upon microbial attributes that mediate cell damage. While the activity of several C. albicans hydrolytic enzymes is well characterized, the biological role of lipases is uncertain. In this report, we identified, isolated, and characterized a C. albicans 70 kDa lipase, that exhibited maximal activity at physiological pH and temperature.  We  evaluated the ability