Artículos
Título:
Beta-galactoside-binding lectins or galectins are a family of closely related carbohydrate-binding proteins which functions still remain to be elucidated. Several evidence suggest they could play a role in different biological processes, such as cell grow
Autor/es:
RABINOVICH GA; MODESTI N; CASTAGNA L; LANDA C; RIERA CM; SOTOMAYOR CE
Editorial:
OXFORD UNIV PRESS
Referencias:
Lugar: Oxford; Año: 1997 vol. 122 p. 365 - 365
Resumen:
À-Galactoside-binding lectins or galectins are a family of closely related carbohydratebinding
proteins which functions still remain to be elucidated. Several evidence suggest
they could play a role in different biological processes, such as cell growth regulation and
immunomodulation. In the present study we report that affinity-purified CLL-I (chicken
lactose lectin-I), an acidic 16-kDa galectin exhibits specific growth regulatory properties.
Con A-stimulated rat spleen mononuclear cells showed a marked dose-dependent growth
inhibition upon incubation with the galectin protein. Cell growth arrest was highly
prevented by galectin-specific sugars. In addition, biochemical, cytofluorometrical, and
morphological evidence are also provided to show that these inhibitory properties are
related to a positive control in the apoptotic threshold of spleen mononuclear cells. Flow
cytometric analysis showed a dose- and time-dependent increase of cells with hypodiploid
DNA content upon