Candida albicans up-regulates the Fas-L expression in liver Natural Killer and Natural Killer T cells

RENNA MS; FIGUEREDO CM; RODRIGUEZ- GALÁN MC; ICELY PA; CANO R; CEJAS H; CORREA SG; SOTOMAYOR CE

ELSEVIER GMBH

Año: 2015 vol. doi: p. 1 - 1

fter Candida albicans arrival to the liver, the local production of proinflammatory cytokines and the expanded intrahepatic lymphocytes (IHL) can be either beneficial or detrimental to the host. Herein we explored the balance between protective inflammatory reaction and liver damage, focusing our study on the contribution of TNF-ALPHA and Fas-Fas-L pathways in the hepatocellular apoptosis associated to C. albicans infection. A robust tissue reaction and a progressive increase of IL-1BETA, IL-6 and TNF-ALPHA were observed in infected animals. Blocking the biological activity of TNF-ALPHA did not modify the number of apoptotic cells observed in C. albicans infected animals. Fas-L molecule was up regulated on purified hepatic mononuclear cells and its expression progressed with the infection. In the IHL compartment, the absolute number of Fas-L+ NK and NKT cells increased on days 1 and 3 of the infection. C. albicans was also able to up regulate Fas-L expression in normal liver NK and NK