Hepatocellular Apoptosis during C. albicans colonization: involvement of TNF-alpha and infiltrating Fas-L positive lymphocytes.

RENNA MS; CORREA SG; PORPORATTO C; FIGUEREDO CM; PARAJE MG; AOKI MP; SOTOMAYOR CE

OXFORD UNIV PRESS

Año: 2006 vol. 18 p. 1719 - 1719

font face="AdvPSHEL-B" size="1"> The liver constitutes the first barrier in the control of hematogenous dissemination of Candida albicans of intestinal origin. In rats infected with C. albicans, this organ limits the growth of the yeast and mounts an efficient inflammatory reaction. However, in rats infected and exposed to chronic varied stress, the hepatic inflammatory reaction is compromised and the outcoming of the infection is more severe. Although in both groups the fungal burden is associated with hepatotoxicity, steatosis, increment of hepatic enzymes and lipid peroxidation, stress-related differences are clearly evident. Herein, we evaluated in infected and infected-stressed hosts the involvement of