SOTOMAYOR CLAUDIA ELENA
Artículos
Título:
Candida lipases: a review on biochemical, molecular and pathogenic aspects.
Autor/es:
CASTILLO G; AZCURRA AI; SOTOMAYOR CE
Revista:
Rev. Fac. Cien. Med. Univ. Nac. Cba.
Editorial:
Facultad de Ciencias Medicas
Referencias:
Lugar: Córdoba; Año: 2019 vol. 79 p. 59 - 59
ISSN:
1853-0605
Resumen:
n the last half century there was a significant increase in the incidence of fungal infections being likely to become a global health priority. The sophisticated degree of host-Candida interaction is the product of different virulence strategies used by the fungus to invade the tissues and the various defense mechanisms that it develops to control it. There is a significant amount of literature that indicates that this opportunistic commensal fungus has components that can be considered virulence factors related to the stage of the infectious process. Among the virulence factors of this fungus can be mentioned the adherence to cell surfaces, the formation of biofilms and the production of hydrolytic enzymes. The most studied hydrolases secreted by C. albicans are aspartyl proteinases, phospholipases and esterases, while lipases have been the least studied. These enzymes would have the function to facilitate active penetration into the cells, participating in the digestion and synthesi