Immune-metabolic balance in stressed rats during Candida albicans infection

RODRIGUEZ- GALÁN MC, C PORPORATTO, CE SOTOMAYOR, R CANO, H CEJAS AND SG CORREA

STRESS

TAYLOR & FRANCIS LTD

Año: 2010 vol. 13 p. 373 - 373

1025-3890

font face="AdvPS8585" size="1"> We evaluated the host metabolic response to chronic varied stress during infection with the fungus Candida albicans. We used four groups of female Wistar rats: normal uninfected and unstressed, stressed, C. albicans infected and infected, and stressed. Infected rats reacted with rapid metabolic adjustments, evident as anorexia and body weight loss, partly mediated by glucocorticoids and TNF-a. Higher circulating levels of IL-6 and glucose ( p , 0.05) revealed the progress and catabolic effect of the inflammatory response. Infected and stresse