Potential Use of Ascorbic Acid-Base Surfactants as Skin Penetration Enhancers

S.D. PALMA, B. MALETTO, P. LO NOSTRO, R.H. MANZO, M.C. PISTORESI-PALENCIA, D.A. ALEMANDI

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Año: 2006 p. 821 - 821

0363-9045

b> ABSTRACT 6-O-Ascorbic acid alkanoates (ASCn) are amphiphilic molecules having physical-chemical properties that depend on the alkyl chain length. The derivatives of low molecular weight (n < 11) have enough aqueous solubility to produce self-assemblies at room temperature (¡Ö25¡ãC), while those with longer alkyl chains possess a critical micellar temperature (CMT) higher than 30¡ãC. At higher temperatures (T¡ã > CMT), ASCn aqueous suspensions turn into either micellar solutions or gel phases, depending on the length of the hydrophobic chain. On cooling,