Optimization of Microparticle Coating Parameters with Cell Wall of Saccharomyces cerevisiae by Fractional Factorial Design

SOFIA BRIGNONE; SOLEDAD RAVETTI; BELKYS MALETTO; SANTIAGO PALMA

Journal of Pharmaceutical Innovation

Springer New York

Año: 2021

1872-5120

he design of multiparticulate systems is a high-impact technological strategy in the formulation of immunomodulators for oraladministration, fluid bed coating being a technique used due to its versatility and relatively low cost.Purpose The objective of this work was to cover a solid support (Suglets® of Colorcon®) with an extract of cell wall ofSaccharomyces cerevisiae through a fluidized bed system to determine the influence of operation and formulation conditionsin the quality and performance of the product. This was carried out through a fractional factorial design.Methods Evaluating the performance of the coating process, the weight gain of the spheres, the amount of process stops, and themorphological and qualitative analysis of the microparticles coated.Results and conclusion: Although more promising operating conditions were observed, this work verifies that there is not a singlecombination of levels of each factor that provides good results with respect to the performance of