Previous Stress Attenuates the Susceptibility to Midazolam?s

BUSTOS SILVIA GABRIELA 1, MARCELO GIACHERO1, HE´CTOR MALDONADO2 AND VÝ´CTOR ALEJANDRO MOLINA*,1

NATURE PUBLISHING GROUP

Año: 2010 vol. 35 p. 1097 - 1097

font size="1" face="AdvGillSan-L"> Resumen It is well known that, under certain boundary conditions, the retrieval of a stable consolidated memory results into a labile one. During this unstable phase, memory can be vulnerable to interference by a number of pharmacological agents, including benzodiazepines. One of the goals of this study was to evaluate the vulnerability to midazolam (MDZ) after reactivation of recent and remote contextual fear memories in animals that experienced a stressful situation before learning. Animals were subjected to a restraint session and trained in a contextual fear paradigm the following day; consolidated memories were reactivated at different times after learning and different MDZ doses (1.5, 3.0 mg/kg) were administered to rats after reactivation. Our results show that MDZ did