Benzodiazepine withdrawal facilitates the subsequent onset of escape failures and anhedonia: influence of different antidepressant drugs

LACERRA C, MARTIJENA ID, BUSTOS SG, MOLINA VA.

ELSEVIER SCIENCE BV

Año: 1999 vol. 20 p. 40 - 40

p style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">The effect of benzodiazepine_BDZ.withdrawal on escape acquisition and on the behavioral response to two different reinforcing stimuli was investigated. In addition, the influence of antidepressant drugs _AD. differing in their mechanism of action on these behavioral outputs was also evaluated. Rats subjected to withdrawal from a chronic treatment with diazepam _DZM; 2 mgrkg per day, i.p.. during 21 days were subsequently exposed to a brief inescapable shock session _IS. and 48 h later to an active avoidance test. Only withdrawn animals exposed to the IS exhibited enhanced escape failures. In an additional experiment, withdrawn rats were repeatedly administered with vehicle_VEH., desipramine_DMI; 5 mgrkg, i.p, fluoxetine_FLU; 5 mgrkg, i.p..or phenelzine_PHEN; 5 mgrkg,