MIDAZOLAM DISRUPTS FEAR MEMORY RECONSOLIDATION

S. G. BUSTOS,A H. MALDONADOB AND V. A. MOLINAA*

NEUROSCIENCE

Elsevier Ltd on behalf of IBRO.

Año: 2006 vol. 139 p. 831 - 831

0306-4522

b> Abstract—The current research examines the influence of midazolam (MDZ) on memory reconsolidation using a contextual fear paradigm in rats, based on three context-shock training trials (0.7 mA, 3 s). First, we evaluate the effect of MDZ (1 mg/kg, i.p.) injected shortly after the training procedure. Second, we examined the influence of MDZ after a brief exposure (90 s) either in the training context (reactivation procedure) or in a neutral environment (no reactivation procedure) and one day later, freezing behavior was scored when rats were re-exposed to the training environment. Third, we investigate both the effect of MDZ administered at different times following reactivation on fear mem