Autor/es:
MARTINEZ, FERNANDO; KNUBEL, C; SANCHEZ, MARIA CECILIA; CERVI, LAP; MOTRAN, CC
Resumen:
ecause of their plasticity and central role in orchestrating immunity and tolerance,
DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune
response in order to support pregnancy. Here, we show that pregnancy-specific glycoprotein
(PSG1a), the major variant of PSG released into the circulation during pregnancy,
targets DCs to differentiate into a subset with a unique phenotype and function. This
semimature
phenotype is able to secrete IL-6 and TGF-β. PSG1a also affected the maturation
of DCs, preventing the up-regulation of some costimulatory molecules, and inducing the
secretion of TGF-β or IL-10 and the expression of programmed death ligand 1 (PD-L1)
in response to TLR-9 or CD40 ligation. In addition, PSG1a-treated DCs promoted the
enrichment of Th2-type cytokines, IL-17-producing cells, and Treg cells from CD4+ T cells
from DO11.10 Tg mice. Moreover, in vivo expression of PSG1a promoted the expansion
of Ag-specific CD4+CD25+Foxp3+