Pregnancy-specific glycoprotein 1a activates dendritic cells to provide signals for Th17-, Th2-, and Treg-cell polarization.

MARTINEZ, FERNANDO; KNUBEL, C; SANCHEZ, MARIA CECILIA; CERVI, LAP; MOTRAN, CLAUDIA C

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 2012 vol. 42 p. 1573 - 1573

b> Because of their plasticity and central role in orchestrating immunity and tolerance, DCs can respond to pregnancy-specific signals, thus promoting the appropriate immune response in order to support pregnancy. Here, we show that pregnancy-specific glycoprotein (PSG1a), the major variant of PSG released into the circulation during pregnancy, targets DCs to differentiate into a subset with a unique phenotype and function. This semimature phenotype is able to secrete IL-6 and TGF-ß. PSG1a also affected the maturation of DCs, preventing the up-regulation of some costimulatory molecules, and inducing the secretion of TGF-ß or IL-10 and the expression of programmed death ligand 1 (PD-L1) in response to TLR-9 or CD40 liga