Decreased expression of the low-density lipoprotein receptor-related protein-1 (LRP-1) in rats with prostate cancer

GILARDONI MB, CESCHIN DG, SAHORES MM, OVIEDO M, GEHRAU RC, CHIABRANDO GA

J Histochem Cytochem

Baltimore : Williams & Wilkins Co., c1953-

Año: 2003 p. 1575 - 1575

0022-1554

he aim of this work was to evaluate by immunohistochemistry (IHC) the expressionof both LRP-1 and urokinase-type plasminogen activator receptor (uPAR) at differentdevelopmental stages of rat prostate disease by using a prostate cancer model previouslydeveloped in our laboratory. We found that LRP-1 was weakly expressed in normalprostates and in rats with hyperplastic glands. The expression of this receptor increasedand correlated with the degree of premalignant lesions (PIN I, II, and III). The IHC for uPARin normal prostates and in premalignant lesions showed a score of immunostaining thatcorrelated with the expression of LRP-1. On the other hand, in prostates with adenocarcinomasand undifferentiated carcinomas, LRP-1 was undetectable or weakly detected,whereas uPAR showed a significantly higher level of expression. Based on the IHC results inrat prostates with premalignant and malignant lesions and considering that LRP-1, b