Decrease in intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator (uPAR) expression promotes turmor cell spreading in vivo

DONADIO AC, REMEDI MM, FREDE S, BONACCI GR, CHIABRANDO G, PISTORESI-PALENCIA MC

Clinical and Experimental Metastasis

Springer

Año: 2002 vol. 19 p. 437 - 437

0262-0898

p class="MsoBodyText" style="MARGIN: 0cm 1.1pt 0pt 36pt; TEXT-INDENT: 34.8pt; TEXT-ALIGN: justify">The development of an effective antitumor immune response to control tumor growth is influenced by the tumor cell itself and/or by the tumor microenvironment. Tumor invasion and tumor cell spreading require a finely tuned regulation of the formation and loosening of adhesive contacts of tumor cells with the extracellular matrix (ECM). In our laboratory, a rat tumor cell line derived from a spontaneous rat sarcoma revealed, by flow cytometry, a high frequency of intercellular adhesion molecule-1 (ICAM-1, 70.1