Time course of cellular immune response and testosterone metabolism in an autoimmune model for chronic prostatic inflamation (CPI).

DONADIO AC; GAGLIANO H; REMEDI MM; NOWOTNY E; DEPIANTE-DEPAOLI M

JOURNAL OF UROLOGY

Lippincott Willams Wilkins

Año: 1998 vol. 160 p. 1546 - 1546

0022-5347

p class="MsoNormal" style="MARGIN: 0cm 1.1pt 0pt 36pt; TEXT-INDENT: 54pt">PURPOSE: Little is known of the etiology and pathogenesis of chronic inflammatory prostate diseases of noninfectious origin. In our experimental autoimmune rat model for chronic prostatic inflammation (CPI) we evaluated, in a time-course study, the specific cellular immune response to male accessory glands (MAG) and metabolic activity in the prostate gland. Results obtained in CPI rats were compared with data from rats immunized with kidney homogenate as well as from non-treated rats. MATERIALS AND METHODS: Specific cellular immune response against MAG antigen(s) was studied by delayed type hypersensitivity (DTH) and lymphocyte proliferation tests. The prostate 5alpha-reductase activity was studied in prostate homogenates by thin layer chromatography (TLC). RESULTS: DTH values were positive in MAG treated rats sacr