Time course of reactive oxygen intermediates release and histopathological findings during experimental autoimmune prostatitis development

ORSILLES MA, DONADIO AC, DEPIANTE-DEPAOLI M

The Prostate

Wiley InterScience

Año: 1995 vol. 27 p. 50 - 50

0270-4137

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt 36pt">Spontaneous and stimulated reactive oxygen intermediates (ROI) release by peritoneal exudate cells (PEC) and histopathological findings in the prostate gland were assessed during experimental autoimmune prostatitis (EAP) development. Results in EAP rats were compared with data from rats immunized with kidney homogenate, BSA, and CFA, as well as nontreated rats. At 28 days of first immunization (FI), EAP rats spontaneously released significantly more ROI than occurred in the cells from control rats. A similar response was found when ROI release was analyzed after in vitro stimulus. In time course studies, an increased spontaneous O2- production was observed at day 7 after FI, and remained the same during all period studied, (14, 21, and 28 days after FI). The stimulated O2- production showed elevated levels at 7 days after FI and fell afterward to l