Polymorphonuclear cells stimulate the migration and metastatic potential of rat sarcoma cells

MARÍA MÓNICA REMEDI, ANA CAROLINA DONADIO AND GUSTAVO ALBERTO CHIABRANDO

Blackwell Scientific Publications

Lugar: England; Año: 2009 vol. 90 p. 44 - 44

font face="AdvROTIS-SSEB"> Summary Tumour microenvironment, which is largely affected by inflammatory cells, is a cru- cial participant in the neoplastic process through the promotion of cell proliferation, survival and migration. Neutrophils polymorphonuclear cells (PMNs) induce inflam- matory reactions that can be either cytotoxic for tumour cells or can promote tumour growth and metastasis. Previously, we have reported a spontaneous metasta- sis tumour model that presents tumour PMNs infiltration and metastasis in liver and spleen. The aim of this study was to evaluate PMNs influences on tumour cell invasion and metastatic properties. To this end, we analysed intercellular adhesion molecule-1 (ICAM-1), urokinase-type plasminogen activator r