The thyroid hormone Triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity

ALAMINO VA; MONTESINOS MM; RABINOVICH GA; PELLIZAS CG

ONCOIMMUNOLOGY

Taylor & Francis

Lugar: Philadelphia, PA; Año: 2015 vol. 5

2162-402X

endritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy