Control of dendritic cell maturation and function by triiodothyronine (T3)

MASCANFRONI ID; MONTESINOS MM; SUSPERREGUY S; CERVI L; ILARREGUI J; RAMSEYER V; MASINI-REPISO AM; TARGOVNIK HM; RABINOVICH GA; PELLIZAS CG

The Federation of American Societies for Experimental Biology

Lugar: New York, USA; Año: 2008 vol. 22 p. 1032 - 1032

ccumulating evidence indicates a functional crosstalk between immune and endocrine mechanisms in the modulation of innate and adaptive immunity. However, the impact of thyroid hormones (THs) in the initiation of adaptive immune responses has not yet been examined. Here we investigated the presence of thyroid hormone receptors (TRs) and the impact of THs in the physiology of mouse dendritic cells (DCs), specialized antigen-presenting cells with the unique capacity to fully activate naive T cells and orchestrate adaptive immunity. Both immature and lipopolysaccharide-matured bone marrow-derived DCs expressed TRs at mRNA and protein levels, showing a preferential cytoplasmic localization. Remarkably, physiological levels of triiodothyronine (T3) stimulated the expression of DC maturation markers (major histocompatability complex II, CD80, CD86, and CD40), markedly increased the secretion of interleukin-12, and stimulated the ability of DCs to induce naive T cell proliferation