PELLIZAS CLAUDIA GABRIELA
Artículos
Título:
Quercetin 3,7,3',4'-tetrasulphated isolated from Flaveria bidentis inhibits tissue factor expression in human monocyte
Autor/es:
GUGLIELMONE, HA; NUÑEZ-MONTOYA, SC; AGNESE, AM; PELLIZAS CG; CABRERA, JL; DONADÍO, AC
Referencias:
Año: 2012 vol. 19 p. 1068 - 1068
Resumen:
ulphated esters of the flavonoids sulphated quercetin 3,7,3,4-tetrasulphated (QTS) and quercetin 3-
acetyl-7,3,4-trisulphate (ATS), isolated from Flaveria bidentis, have demonstrated anticoagulant and
antiplatelet properties. In this study, we examined if both compounds affected the expression of the
procoagulant tissue factor (TF) induced by lipopolysaccharide (LPS) on human monocyte. Monocytes
were pretreated with different concentrations of each flavonoid (0.1–500 M), followed by a 4 h incubation
with LPS in order to induce TF expression. Results of the TF expression showed different behaviors
for the two flavonoids studied. A slight inhibitory effect on the TF expression was detected at a QTS concentration
of 0.1 M, but from 1 M onwards a significant inhibitory effect that remained up to 500 M
could be observed. In contrast, ATS induced a poor inhibitory effect on TF expression at all concentrations
tested. These results suggest that QTS has another antithrombotic propert