PELLIZAS CLAUDIA GABRIELA
Artículos
Título:
Bacterial lipopolysaccharide increases thyroglobulin gene expression involving TTF-1 and Pax8 transcription factors
Autor/es:
VELEZ ML; COSTAMAGNA E; KIMURA E; FOZZATTI L; PELLIZAS CG; MONTESINOS MM; LUCERO AM; COLEONI AH; SANTISTEBAN P; MASINI-REPISO AM
Referencias:
Año: 2006 vol. 147 p. 3270 - 3270
Resumen:
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The bacterial lipopolysaccharide (LPS) is a biological activator
that induces expression of multiple genes in several cell
types. LPS has been proposed as an etiopathogenic agent in
autoimmune diseases. However, whether LPS affects the expression
of autoantigens has not been explored. Thyroglobulin
(TG) is a key protein in thyroid hormonogenesis and one
of the major thyroid autoantigens. This study aimed to analyze
the action of LPS on TG gene expression in Fisher rat
thyroid cell line FRTL-5 thyroid cells. We demonstrate that
LPS increases the TSH-induced TG protein and mRNA level.
Evidence that the effect of LPS is exerted at the transcriptional
level was obtained by transfecting the minimal T