Thyroid hormone receptor ƒÒ1 gene expression is increased by dexamethasone at transcriptional level in rat liver

MONTESINOS MM; PELLIZAS CG; VÉLEZ ML; SUSPERREGUY S; MASINI-REPISO AM; COLEONI AH

LIFE SCIENCES

Elsevier

Año: 2006 vol. 78 p. 2584 - 2584

0024-3205

font face="AdvTT5843c571" color="#231f20" size="1"> Triiodothyronine (T3) exerts most of its effect through nuclear thyroid hormone receptors (TR) which bind mainly as heterodimers with retinoid-X receptors (RXR) to thyroid hormone response elements (TRE) in target genes. It is well known that the synergistic interaction of T3 and glucocorticoids has a role on the synthesis of growth hormone in rat pituitary cell lines and in the T3-induced metamorphosis in amphibians. Glucocorticoids increased mRNAs of T3