Thyroid Hormone Action on Innate Immunity

MONTESINOS, MARÍA DEL MAR; PELLIZAS, CLAUDIA

Frontiers in Endocrinology

Frontiers

Lugar: Lausanne; Año: 2019 vol. 10 p. 1 - 1

he interplay between thyroid hormone action and the immune system has beenestablished in physiological and pathological settings. However, their connection iscomplex and still not completely understood. The thyroid hormones (THs), 3,3′,5,5′tetraiodo-L-thyroxine (T4) and 3,3′,5-triiodo-L-thyronine (T3) play essential roles in boththe innate and adaptive immune responses. Despite much research having beencarried out on this topic, the available data are sometimes difficult to interpret or evencontradictory. Innate immune cells act as the first line of defense, mainly involvinggranulocytes and natural killer cells. In turn, antigen presenting cells, macrophagesand dendritic cells capture, process and present antigens (self and foreign) to naïve Tlymphocytes in secondary lymphoid tissues for the development of adaptive immunity.Here, we review the cellular and molecular mechanisms involved in T4 and T3 effects oninnate immune cells. An overview of the state-of-the-art of