Antibacterial effects of extracts obtained from plants of Argentina: Bioguided isolation of compounds from the anti-infectious medicinal plant Lepechinia meyenii

CHABÁN, MACARENA FUNES; KARAGIANNI, CATHERINE; JORAY, MARIANA BELÉN; TOUMPA, DIMITRA; SOLA, CLAUDIA; CRESPO, MARÍA INÉS; PALACIOS, SARA MARÍA; ATHANASSOPOULOS, CONSTANTINOS M.; CARPINELLA, MARÍA CECILIA

JOURNAL OF ETHNOPHARMACOLOGY

ELSEVIER IRELAND LTD

Año: 2019 vol. 239

0378-8741

thnopharmacological relevance: The mostly native species from Argentina are used in traditional medicine generally for the treatment of pain and inflammation, respiratory, gastro-intestinal and urinary disorders and as antiseptics. Aim of the study: Since these ailments may be associated with bacterial infections and that it is necessary to discover alternative compounds with antibacterial activity, 69 extracts from these plants were screened for their activity against pathogenic bacteria. The most effective extract was then submitted to bioguided isolation to obtain the compounds responsible for this activity. Materials and methods: Extracts and fractions were screened using agar dilution, and compounds using microbroth dilution methods. A large panel of pathogenic bacteria was used, especially methicillin-susceptible Staphylococcus aureus (MSSA)and methicillin-resistant S. aureus (MRSA). Bioguided fractionation was performed using successive chromatographic techniques, while the che