Spread of Epidemic MRSA-ST5-IV clone Encoding PVL as a Major Cause of Community Onset Staphylococcal Infections in Argentinean Children

CLAUDIA SOLA; HUGO PAGANINI; ANA L EGEA; ALEJANDRO J MOYANO; ANALIA GARNERO; INES KEVRIC; CATALINA CULASSO ; ANA VINDEL; STUDY GROUP OF CA-MRSA IN CHILDREN, ARGENTINA-2007; HORACIO LOPARDO; JOSE LUIS BOCCO

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2012 vol. 7 p. 30487 - 30487

1932-6203

ackground:Community-associated methicillin-resistant Staphylococcus aureus-(CA-MRSA) strains have emerged in Argentina. We investigated the clinical and molecular evolution of community-onset MRSA infections (CO-MRSA) in children of Córdoba, Argentina, 2005-2008. Additionally, data from 2007 were compared with the epidemiology of these infections in other regions of the country.Methodology/Principal Findings: Two datasets were used: i) lab-based prospective surveillance of CA-MRSA isolates from 3 Córdoba pediatric hospitals-(CBAH1-H3) in 2007-2008 (compared to previously published data of 2005) and ii) a sampling of CO-MRSA from a study involving both, healthcare-associated community-onset-(HACO) infections in children with risk-factors for healthcare-associated infections-(HRFs), and CA-MRSA infections in patients without HRFs detected in multiple centers of Argentina in 2007.Molecular typing was performed on the CA-MRSA-(n: 99) isolates from the CBAH1-H3-dataset and on the HACO-MRSA