Differential expression patterns of purinergic ectoenzymes and the antioxidative role of IL-6 in hospitalized COVID-19 patient recovery

MAZZOCCO, YANINA LUCIANA; BERGERO, GASTÓN; DEL ROSSO, SEBASTIAN; EBERHARDT, NATALIA; SOLA, CLAUDIA; SAKA, HÉCTOR ALEX; VILLADA, SOFÍA MARÍA; BOCCO, JOSÉ LUIS; AOKI, MARIA PILAR

Frontiers in Immunology

Frontiers Media SA

Lugar: Lausanne; Año: 2023 vol. 14

ntroduction: We have acquired significant knowledge regarding the pathogenesis of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2). However, the underlying mechanisms responsible for disease recovery still need to be fully understood. Methods: To gain insights into critical immune markers involved in COVID-19 etiopathogenesis, we studied the evolution of the immune profile of peripheral blood samples from patients who had recovered from COVID-19 and compared them to subjects with severe acute respiratory illness but negative for SARS-CoV-2 detection (controls). In addition, linear and clustered correlations between different parameters were determined. Results: The data obtained revealed a significant reduction in the frequency of inflammatory monocytes (CD14+CD16+) at hospital discharge vs. admission. Remarkably, nitric oxide (NO) production by the monocyte compartment was significantly reduced at discharge. Furthermore, interleukin (IL)-6 plasma levels were neg