Congresos y reuniones científicas
Título:
EVOLUTION OF METHICILLIN-RESISTANT CLONES IN THE COMMUNITY AND HOSPITAL SETTING, ARGENTINA
Autor/es:
ANA L EGEA; ALEJANDRA CORSO; RICARDO LAMBERGHINI; GAGETTI P; FACCONE D; LUCERO C; BOCCO, JOSE LUIS; SOLA CLAUDIA
Reunión:
Congreso; Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y. Biología Molecular (SAIB-2012); 2012
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y. Biología Molecular
Resumen:
S.
aureus
MRSA is a successful healthcare (HA) and community (CA)
associated pathogen showing high virulence. We aimed to
investigate themolecular epidemiology ofMRSAinfections in both
community and hospital setting inArgentina. Consecutive S.aureus
clinical isolates were collected during Nov-2009 from 66 hospitals
in 20 Argentina provinces and Buenos Aires city. Healthcare-onset
(HO) infection was defined when MRSA was obtained after 48
hours of hospitalization.AMRSAwas considered an HAstrain if it
was resistant to at least 2 non-beta-lactam antibiotics. MRSA were
studied by local and global molecular typing. Out of 591 total
isolates, 375 (63%) were from community-onset (CO)
infections and 322 (54%) were MRSA (37% CA and 17% HA).
MRSAproportion differed significantly between CO(58%) andHO
(49%) infections. The molecular typing determined that most
harbored SCCmecIV (74%) (IVc, 35%, IVa, 31% and minor
variants) followed by SCCmecI (20%). CO-infections were
associated mainly to PFGE type N-ST30-SCCmecIVc-t019-PVL+
(46%) and I-ST5-SCCmecIVa-t311-PVL+ (37%) clones. In
contrast, HO-infections were associated mainly to PFGE type A-
ST5-SCCmecI-t149 (46%) and I-ST5-SCCmecIVa-t311-PVL+
(20%) clones.The epidemiology ofMRSAis changing inArgentina,
with higher rates in the CO- than in the HO-infections, mainly
associated with the spread of two CA-MRSA clones harboring
SCCmecIV.