An efficient ternary complex of acetazolamide with HP-ß-CD and TEA for topical

S. D. PALMA, L. I. TARTARA, D. QUINTEROS, D.A. ALLEMANDI, M.R. LONGHI, G.E. GRANERO

Elsevier

Año: 2009 vol. 138 p. 24 - 24

font face="AdvTT5235d5a9" color="#231f20" size="1"> In order to enhance the ocular bioavailability of acetazolamide (ACZ), a multicomponent complex with hydroxypropyl-ß-cyclodextrin (HP-ß-CD) and triethanolamine (TEA) was prepared to be applied topically. In vitro corneal permeation across isolated rabbit cornea of proposed ACZ formulations and the marketed AZOPT® formulation (1%w/v brinzolamide)was studied. Formulationswere also tested for their effect on the intraocular press