TERNARY COMPLEXES OF FLURBIPROFEN WITH HP-ß-CD AND ETHANOLAMINES. CHARACTERIZATION AND TRANSDERMAL DELIVERY.

M. MAITRE, M. LONGHI AND G. GRANERO

TAYLOR & FRANCIS INC

Año: 2007 vol. 33 p. 1 - 1

nbsp; Binary and multicomponent systems complexes prepared with HP-ß-CD and/or with monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA) were obtained.  The results of solid-state studies indicated the presence of strong interactions between the  components in the binary and the ternary systems. Drug solubility and dissolution rate in  water were notably improved by employing the HP-ß-CD and the alkanolamines. The  combined use of cosolvency and complexation with MEA in the presence of HP-ß-CD on the  permeation of flurbiprofen through the human skin was evaluated. The combination of IPM,  PG and HP-ß-CD yield the highest permeation for the flurbiprofen:MEA complex.