Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-â-CD and monoethanolamine and in vitro transdermal evaluation

MARIA J MORA, MARCELA R LONGHI, GLADYS E GRANERO

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Año: 2010 p. 4079 - 4079

font face="AdvOT863180fb" size="1"> Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-b-cyclodextrin (M-b-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-b-CD. However, the DCF solubility increas