Rapid in vivo dissolution of ketoprofen: implications on the biopharmaceutics classification system

G.E. GRANERO, C. RAMACHANDRAN, G.L. AMIDON

GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH

Año: 2006 p. 673 - 673

p class="MsoBodyText" style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 150%">The aim of this paper was to investigate the in vivo dissolution behavior of ketoprofen, a Class II drug according to the BCS, in the upper small intestine of dog using an intubations method, where no blocking balloons were used to prevent luminal drug transport along the GI tract.  Our design allowed the drug to be transported freely to more distal parts of the GI tract and also, it was supported by a pharmacokinetic study.  Pharmacokinetic parameters of ketoprofen were determined in dogs after administering ~