Layered double hydroxides-indomethacin nanohybrids: intercalation, pH influence, stability and release properties

MENDIETA SILVIA; OLIVA MARCOS; PEREZ CELSO; REYES NUÑEZ PATRICIO; LONGHI MARCELA; GRANERO GLADYS; CRIVELLO MONICA

World Journal of Pharmaceutical Sciences

Atom and Cell Publishers ©

Año: 2016 vol. 4 p. 276 - 276

n this work, three pH values (8, 9 and 10) were studied for the insertion of Indomethacin (Indo) molecules intoLayered Double Hydroxides (LDHs). The obtained results showed that the LDH materials have been a goodstorage for the drug. LDHs provide thermal stability with an increase in the thermal decomposition of the drugaround 100°C more. Indo into LDHs exhibited higher photostability to UV light irradiation. In vitro drug releaseexperiments in a phosphate buffer solution (pH = 7.4) have been carried out. The loading amount of intercalatedIndo was increased to 66 % at pH 8, and showed a profile of sustained release of 97 % in 8h. The releaseprofiles were fitted by mathematical models, which describe various kinetic models that served to investigatethe drug release mechanism, being the Bhaskar kinetics model the most appropriate. The results showed that thenanohybrids can be used as an effective drug delivery system