Synthesis and release behavior of layered double hydroxides?carbamazepine composites

PERALTA MARIA FLORENCIA; MENDIETA SILVIA; SCOLARI ROMINA; GRANERO G.E.; CRIVELLO MONICA

Scientifc Reports

Springer Nature

Año: 2021

arbamazepine (CBZ) was incorporated into layered double hydroxides (LDH) to be used as acontrolled drug system in solid tumors. CBZ has a formal charge of zero, so its incorporation in theanionic clay implies a challenge. Aiming to overcome this problem, CBZ was loaded into LDH withsodium cholate (SC), a surfactant with negative charge and, for comparison, without SC by thereconstruction method. Surprisingly, it was found that both resultant nanocomposites had similarCBZ encapsulation efficiency, around 75%, and the LDH-CBZ system without SC showed a betterperformance in relation to the release kinetics of CBZ in simulated body fluid (pH 7.4) and acetatebuffer simulating the cellular cytoplasm (pH 4.8) than the system with SC. The CBZ dimensions weremeasured with Chem3D and, according to the basal spacing obtained from X-ray patterns, it can bearranged in the LDH-CBZ system as a monolayer with the long axis parallel to the LDH layers. Fouriertransform infrared spectroscopy and solid s