Exploring ZnO Nanoparticles in Antibiotic Therapy

GRANERO G.

Determinations in Nanomedicine & Nanotechnology

Crimson Publishers

Año: 2022 p. 1 - 1

2832-4439

oday, the raise in the rate of infectious diseases and the emergence of Multidrug-Resistant (MDR)bacteria has resulted in an increased number of associated hospital-acquired and community-acquiredinfections and mortality, so there is an urgent need to develop alternative antimicrobial strategies. Forthis purpose, zinc oxide nanoparticles (ZnO NPs) have demonstrated potent antibacterial activity andbiocompatibility. In contrast to the conventional antibiotics, they are able to inhibit or interfere withbacterial Quorum Sensing (QS) and biofilm formation. Also, they are less sensitive to the development ofresistance towards microorganisms. In addition, their zinc?s immunomodulatory effects contribute to theantimicrobial activity of conventional antibiotics. Moreover, there have been reported synergistic effectsof ZnO NPs with various antibiotics. However, it is important to note that even though ZnO NPs have a widerange of antibacterial activities toward various microorganisms; their ant