Development of an antimicrobial agent with a promissing use in wound healing managemen

Congreso; XLVIII Reunión Anual de la Sociedad Argentina de Farmacología Experimental (SAFE); 2019

In the vast world of medicine there are several fields of study of interest; one of them is wound healing. Wounding leads to exposure of subcutaneous tissue that provides a nutritious environment conductive to microbial colonization and proliferation. The presence of bacteria at the wound site down regulates the host immune response, ultimately delaying the natural wound healing process, making the total healing time unpredictable. The usefulness of silver as an antimicrobial agent has been known for a long time, which is especially important in the topical antibacterial treatment of burn wound. The most widely used reagents used as antimicrobial agents for burn wounds have been silver nitrate and silver sulfonamides. However, they have showed a limited clinical usefulness.The aim of this work is to develop a new water-soluble silver complex formed with Triethanolamine (TEA) and Silver Nitrate (AgNO3) for use in wound healing treatment. The antimicrobial activity of the developed silver complex was tested against the pathogenic bacteria S. aureus by determining its Minimum Inhibitory Concentration (MIC). Also, it was assessment the potential cytotoxicity effects in Fibroblasts L929.Antimicrobial results showed that the silver complex displays effective antimicrobial activity comparable to MIC values of AgNO3 and good cytocompatibility.This study sets a platform for further work for the use of the novel developed silver complex from the wound care application perspective.