Organophosphate pesticides phosmet and chlorpyrifos effects on JEG-3 cells survival and inflammatory molecules production: a comparative study

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2012 p. 406 - 406

font size="1" face="AdvGulliv-R"> Epidemiological data have associated environmental organophosphate insecticide (OP) exposure during pregnancy with fetal growth deficits. To better understand OP injury that may adversely affect pregnancy, we used the JEG-3 choriocarcinoma cell line, which provide a recognized in vitro model to study placental function. The effects of the OP phosmet (Pm) and chlorpyrifos (Cp) on JEG-3 cells viability, proliferation, cell cycle and inflammatory molecule production were evaluated. Both insecticides affected cellular viability in a concentration- and time-dependent manner, inducing apoptosis and decreasing [