Expression of Toll-like receptor 4 in the prostate gland and its association with

GATTI G, QUINTAR AA, ANDREANI V, NICOLA JP, MALDONADO CA, MASINI-REPISO AM, RIVERO VE, MACCIONI M,

WILEY-LISS, DIV JOHN WILEY & SONS INC

Año: 2009 vol. 15 p. 1387 - 1387

ACKGROUND: Chronic inflammation has been postulated to be an important drivingforce to prostate carcinoma. Toll-like receptors (TLRs) compose a family ofreceptors mainly expressed on immune cells. Recently, functional TLRs have beenshown to be also expressed in numerous cancer cells, but their significance hasonly recently begun to be explored. The purpose of this study was to investigate the putative role of TLR4 expression in prostate carcinoma. METHODS: To determineif there is an association between TLR4 expression and the malignancy of thetumor, 35 prostate carcinoma samples showing different Gleason grades wereanalyzed by immunohistochemistry. Also, to explore the functionality of thereceptors expressed on the epithelium, we analyzed the type of cytokine response elicited and the signaling pathways involved after TLR4 triggering in the humanprostate adenocarcinoma cell line, DU-145. RESULTS: TLR4 is expressed in th