Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in Experimental Autoimmune Prostatitis

MARIA LAURA BRESER; RUBEN DARIO MOTRICH; JUAN PABLO MACKERN-OBERTI; LEONARDO SANCHEZ; RIVERO VIRGINIA

AMER ASSOC IMMUNOLOGISTS

Lugar: Bethesda; Año: 2013 vol. 190 p. 3121 - 3121

p style="TEXT-ALIGN: justify; LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none" class="MsoNormal">Experimental Autoimmune prostatitis (EAP) is considered a valid a model for the human disease Chronic Nonbacterial Prostatitis.  In the present report we analyze phenotypic characteristics of T cells that gain access to prostate and induce leukocyte recruitment in mice with different susceptibility to EAP. After EAP induction, NOD mice developed a specific cellular response characterized by a mixed Th1/Th17 pattern, with specific T cells mainly expressing CXCR3 that could infiltrate and damage the pro