Antigen-induced inhibition of autoimmune response to rat male accessory glands:

RIVERO VE; FERRO ME; ROMERO-PIFFIGUER M; CORREA S; YRANZO-VOLONTÉ N; RIERA CM

WILEY-V C H VERLAG GMBH

Lugar: Weinheim; Año: 1991 vol. 21 p. 1141 - 1141

he present report describes different aspects of two populations of peritonealcells (PC) obtained from rats injected i.p. 2 h or 24 h previously with asuppressor dose of a purified fraction (FI) of rat male accessory glands (RAG)(FI-PC2h and FI-PC24h, respectively). The FI-PC2h, which are mainly I-E (OX17)positive and can suppress the autoimmune response to RAG autoantigens, have anelevated phagocytic activity against Candida albicans and capacity to reduce the dye nitroblue tetrazolium. In contrast, FI-PC24h, which are mainly I-A (OX6)positive and can potentiate the autoimmunity to RAG autoantigens, have adiminished capacity to reduce the dye and a diminished phagocytic activity.Moreover, the Toxoplasma gondii appear to have a different effect on bothpopulations. The parasites can invade FI-PC2h while FI-PC24h offer resistance to T. gondii aggression. FI-PC2h cultured during 22 h (FI-PC2-24h in vitro), or PCobtai