Effect of gangliosides in the autoimmune response induced by liposome associated antigens

CORREA SG; RIVERO VE; YRANZO-VOLONTÉ N; ROMERO-PIFFIGUER M; FERRO ME; , RIERA CM

TAYLOR & FRANCIS LTD

Lugar: Londres; Año: 1993 vol. 15 p. 195 - 195

model of autoimmunity to rat male accessory glands (RAG) was recently developedby intraperitoneal administration of three doses of native RAG associated withliposomes. In this work we analysed the effects of gangliosides in the cellularresponse to RAG when they were intraperitoneally administrated prior to thesecond dose of liposome-associated RAG. Results show that the gangliosidetreatment could modify an established DTH response. Also, gangliosides markedlyreduced the number of Ia antigen-positive peritoneal exudated cells (PEC).However, they modified neither the processing of liposomes through PEC nor their viability. Moreover, we obtained cellular response by transferring PEC fromimmunized donors into naive receptors