Non-obese Diabetic (NOD) mice are genetically susceptible to Experimental Autoimmune

RIVERO VE; CAILLEAU C; DEPIANTE-DEPAOLI M ; RIERA CM; CARNAUD C

ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 1998 vol. 11 p. 603 - 603

odents develop inflammatory, non-infectious, prostatitis upon autoimmuniz-ation with male accessory gland (MAG) extracts in complete Freund´s adjuvant (CFA).Although there appears to be differences among strains, with respect tosusceptibility to induction, specific details are not known about the geneticbases of such differences. Because NOD mice have inherited a geneticpredisposition to autoimmune lesions affecting, apart from the islets ofLangerhans, a large array of secretory glands such as salivary glands, thyroid,parathyroids and adrenal cortex, we selected this strain to assess the influence of inherited genes upon experimentally-induced autoimmune prostatitis (EAP).Indeed, MAG extracts injected into young NOD males in association with CFA cause a severe inflammatory reaction in the prostate, accompanied by a humoral and Tcell-mediated response. NOD mice develop a more aggressive form of EAP thanWistar rats,