Suppression of experimental autoimmune encephalomyelitis (EAE) by intraperitoneal

RIVERO VE; MACCIONI M; BUCHER AE; ROTH GA; RIERA CM

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 1997 vol. 72 p. 3 - 3

ntraperitoneal (i.p.) treatment of Wistar rats with bovine myelin (BM) or myelinbasic protein (MBP) previously to immunization with BM-CFA showed a diminishedincidence and severity of experimental autoimmune encephalomyelitis (EAE) (2/13and 0/7, respectively) when compared with rats immunized with BM-CFA (11/17) ori.p. treated with ovalbumin (2/4). Concomitantly, animals treated with BM or MBP exhibited a marked reduction of proliferative response to MBP which was highlypositive when spleen mononuclear cells from nontreated and ovalbumin treatedanimals were assayed. Rats that were treated with MBP before immunization produceIgA, IgM, total IgG and subclasses of IgG, IgG2a, IgG2b, IgG2c specific for MBPin similar levels than those observed in nontreated immunized animals. However, ahigher incidence and level of IgG1 was observed in MBP treated rats, meanwhilerats i.p. treated with total BM showed a highly reduced humoral