Cow's milk stimulated lymphocyte proliferation and TNFalpha secretion in hypersensitivity to cow's milk protein

MOTRICH RD; GOTTERO C; REZZONICO C; REZZONICO C; RIERA CM; RIVERO VE

ACADEMIC PRESS INC ELSEVIER SCIENCE

Lugar: Amsterdam; Año: 2003 vol. 109 p. 203 - 203

lthough there is no reliable single laboratory test available for the diagnosis of cow's milk allergy, if an allergic mechanism is suspected, a number oflaboratory studies may be useful in delineating specific proteins responsible forthese disorders. In the current study we analyzed in vitro lymphocyteproliferation assays, specific secretion of TNFalpha in supernatant cultures and specific IgE, IgG, and IgA in a group of patients with hypersensitivity to cow's milk antigens. The stimulation index against a cow's milk antigen mixture,alpha-lactalbumin, beta-lactoglobulin, and casein was significant higher in thegroup of patients maintained on cow's milk-free diet for less than 4 monthscompared with the values observed in the control group and in the group ofpatients without a close contact to cow's milk proteins. A significant increasein TNF-alpha secretion was observed in supernatants from patients with closeconta