IFN b produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response

NUÑEZ N; ANDREANI V; CRESPO I; NOCERA D; BRESER L; ,MORON G; DEJAGER L, ; , LIBERT C; RIVERO V; MACCIONI M

CANCER RESEARCH

AMER ASSOC CANCER RESEARCH

Año: 2012 p. 592 - 592

0008-5472

font size="1" face="AdvOTe4bfdd46"> Toll-like receptor (TLR) ligands may be a valuable tool to promote antitumor responses by reinforcing antitumor immunity. In addition to their expression in immune cells, functional TLRs are also expressed by many cancer cells, but their significance has been controversial. In this study, we examined the action of TLR ligands on tumor pathophysiology as a result of direct tumor cell effects. B16 murine melanoma cells were stimulated in vitrofi