Application of a biarylarsine ligand in Heck and Stille reactions

GISELA J. QUINTEROS; PAULA M. UBERMAN; SANDRA E. MARTÍN

Blucher Chem. Proceedings

Editora Blucher

Lugar: San Pablo; Año: 2013 vol. 1

2318-4043

pplication of a biarylarsine ligand in Heck and Stille reactions Quinteros, Gisela J.; Uberman, Paula M. and Martín, Sandra E.* INFIQC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000-Córdoba, Argentina. *e-mail martins@fcq.unc.edu.ar Keywords: biarylarsine ligand, Heck reaction, Stille reaction INTRODUCTION The Pd coupling reactions are widely used in organic synthesis. Among this group, the Heck reaction occupies a main role in the arylation of alkenes, with wide application in the synthesis of natural products.1 Moreover, the Stille reaction is a powerful method in organic synthesis due to its broad functional group tolerance and the stability of the reagents.2 In the last years, developments in coupling reactions are based on designing selective and stable ligands. Although phosphines ligands play a preponderant role in this field, arsines have shown to be excellent supporting ligands,3 but relatively few have been prepared an