Synthesis of linear D-alt-L peptidomimetics starting from a carbohydrate precursor

SOL C. PARAJÓN PUENZO; ADRIANA A. KOLENDER; SANDRA E. MARTÍN; OSCAR VARELA

Blucher Chemistry Proceedings

Editora Blucher

Lugar: San Pablo; Año: 2011 vol. 1

2318-4043

ynthesis of linear D-alt-L peptidomimetics starting from a carbohydrate precursor Sol C. Parajón Puenzo, Adriana A. Kolender, Sandra E. Martín, Oscar Varela* Dpto. Química Orgánica, CIHIDECAR-CONICET-UBA, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina ? INFIQC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina *e-mail varela@qo.fcen.uba.ar Keywords: peptidomimetics, oligopeptides, carbohydrates INTRODUCTION Fundamental building blocks used by nature are amalgamated to produce natural-like, yet unnatural, structural entities with multifunctional groups anchored in a single ensemble. For example, hybrid molecules that maintain the basic structure of a carbohydrate have been obtained. This hybrids include amino and carboxyl functional groups, characteristic of amino acids. Diverse arrays of peptidic templates have been employed for the construction of homo- and heterooligomers that behave as peptidomime