Synthesis Of New Chiral Bis-Arsine Ligands Based On Natural Carbohydrates

SOL C. PARAJÓN PUENZO; JOAQUÍN ARATA BADANOA; MARTIN G. LOPEZ VIDAL; OSCAR VARELA; SANDRA E. MARTÍN

Blucher Chemistry Proceedings

Editora Blucher

Lugar: San Pablo; Año: 2013 vol. 1

2318-4043

bstract:Transition-metal-catalyzed asymmetric allylic substitutions have become one of the most powerful tools for asymmetric C−C bond formation. Chiral diphosphine ligands have been some of the largest classes of ligands used in asymmetric substitutions. Trost developed the chiral ligand 1 (Fig. 1), which played a crucial role in the improvement of Pd-catalyzed asymmetric substitutions. Based on the Trost modular ligand (TML) system 3 (Fig. 1) a family of ligands has been prepared. We recently reported the synthesis and application of the novel chiral bis-arsine ligand 2 derived from TML. Currently, significant attention has been turned towards the use of chiral ligands based on natural carbohydrates. Herein, we describe the synthesis of a chiral bis-arsine ligand such as 2 containing the chiral scaffold derived from a carbohydrate.